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TargetPeripheral-Type Benzodiazepine Receptor
LigandBDBM50011487
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1352881
Ki 1.5±n/a nM
Citation Castellano, STaliani, SViviano, MMilite, CDa Pozzo, ECosta, BBarresi, EBruno, ACosconati, SMarinelli, LGreco, GNovellino, ESbardella, GDa Settimo, FMartini, C Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors. J Med Chem57:2413-28 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peripheral-Type Benzodiazepine Receptor
Name:Benzodiazepine receptors; peripheral & central
Synonyms:Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR)
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM50011487
NameBDBM50011487
Synonyms:CHEMBL3261897
TypeSmall organic molecule
Emp. Form.C25H23N3O
Mol. Mass.381.4696
SMILESCCN(Cc1ccccc1)C(=O)c1nc(-c2ccc(C)cc2)c2ccccc2n1
Structure
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