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Target
Translocator protein
Ligand
BDBM50012191
Substrate
n/a
Meas. Tech.
ChEMBL_1353749 (CHEMBL3266314)
IC50
680±n/a nM
Citation
 Naidoo, J; De Jesus-Cortes, H; Huntington, P; Estill, S; Morlock, LK; Starwalt, R; Mangano, TJ; Williams, NS; Pieper, AA; Ready, JM Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties. J Med Chem 57:3746-54 (2014) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50012191
Synonyms:
CHEMBL3265237
Type:
Small organic molecule
Emp. Form.:
C21H18Br2FN3O
Mol. Mass.:
507.194
SMILES:
COc1cccc(NC[C@@H](F)Cn2c3ccc(Br)cc3c3cc(Br)ccc23)n1 |r|
Structure:
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