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TargetMenin
LigandBDBM50366388
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1351942
Kd 15600±n/a nM
Citation Li, LZhou, RGeng, HYue, LYe, FXie, YLiu, JKong, XJiang, HHuang, JLuo, C Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface. Bioorg Med Chem Lett24:2090-3 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Menin
Name:Menin
Synonyms:MEN1 | SCG2
Type:Protein
Mol. Mass.:68022.55
Organism:Homo sapiens (Human)
Description:O00255
Residue:615
Sequence:
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHL
ALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKME
VAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGR
PDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCR
EDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLR
FYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEA
REGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTA
QVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTP
SDYTLSFLKRQRKGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50366388
NameBDBM50366388
Synonyms:NEOMYCIN | NEOMYCIN A
TypeSmall organic molecule
Emp. Form.C23H46N6O13
Mol. Mass.614.6437
SMILESNCC1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@H]3[C@H](O)[C@@H](N)C[C@@H](N)[C@@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@@H](N)[C@H](O)[C@H]1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a