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TargetDual specificity mitogen-activated protein kinase kinase 1
LigandBDBM50014412
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1350728
IC50 1.8±n/a nM
Citation Lu, HTu, WFei, HXu, GHu, QZhang, LLin, BYuan, JYin, JGong, AWan, MWang, DZhu, XFeng, JWang, QSun, P Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors. Bioorg Med Chem Lett24:2555-9 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 1
Name:Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | Mitogen-activated protein kinase 1 (MEK1)
Type:Other Protein Type
Mol. Mass.:43439.03
Organism:Homo sapiens (human)
Description:Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates.
Residue:393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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BDBM50014412
n/a
NameBDBM50014412
Synonyms:PIMASERTIB | Pimasertib
TypeSmall organic molecule
Emp. Form.C15H15FIN3O3
Mol. Mass.431.2008
SMILES[H][C@@](O)(CO)CNC(=O)c1ccncc1Nc1ccc(I)cc1F |r|
Structure
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