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Target
Aromatic-L-amino-acid decarboxylase
Ligand
BDBM50017566
Substrate
n/a
Meas. Tech.
ChEMBL_1363990 (CHEMBL3295577)
IC50
1340000±n/a nM
Citation
 Cheng, P; Zhou, J; Qing, Z; Kang, W; Liu, S; Liu, W; Xie, H; Zeng, J Synthesis of 5-methyl phenanthridium derivatives: a new class of human DOPA decarboxylase inhibitors. Bioorg Med Chem Lett 24:2712-6 (2014) [PubMed]  Article 
Target
Name:
Aromatic-L-amino-acid decarboxylase
Synonyms:
AADC | DDC | DDC_HUMAN
Type:
PROTEIN
Mol. Mass.:
53931.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_83
Residue:
480
Sequence:
MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
  
Inhibitor
Name:
BDBM50017566
Synonyms:
CHEBI:7578 | NITIDINE
Type:
Small organic molecule
Emp. Form.:
C21H18NO4
Mol. Mass.:
348.3714
SMILES:
COc1cc2c[n+](C)c3c(ccc4cc5OCOc5cc34)c2cc1OC
Structure:
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