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Target
Aromatic-L-amino-acid decarboxylase
Ligand
BDBM50017568
Substrate
n/a
Meas. Tech.
ChEMBL_1363990 (CHEMBL3295577)
IC50
2690000±n/a nM
Citation
 Cheng, P; Zhou, J; Qing, Z; Kang, W; Liu, S; Liu, W; Xie, H; Zeng, J Synthesis of 5-methyl phenanthridium derivatives: a new class of human DOPA decarboxylase inhibitors. Bioorg Med Chem Lett 24:2712-6 (2014) [PubMed]  Article 
Target
Name:
Aromatic-L-amino-acid decarboxylase
Synonyms:
AADC | DDC | DDC_HUMAN
Type:
PROTEIN
Mol. Mass.:
53931.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_83
Residue:
480
Sequence:
MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
  
Inhibitor
Name:
BDBM50017568
Synonyms:
CHEMBL3288323
Type:
Small organic molecule
Emp. Form.:
C16H15ClFNO2
Mol. Mass.:
307.747
SMILES:
[Cl-].COc1cc2c[n+](C)c3ccc(F)cc3c2cc1OC
Structure:
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