| Reaction Details |
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 | Report a problem with these data |
| Target | NR2B Channel Blocker |
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| Ligand | BDBM50445062 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1365631 |
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| EC50 | 400±n/a nM |
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| Citation |  Atigadda, VR; Xia, G; Desphande, A; Boerma, LJ; Lobo-Ruppert, S; Grubbs, CJ; Smith, CD; Brouillette, WJ; Muccio, DD Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J Med Chem57:5370-80 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NR2B Channel Blocker |
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| Name: | Retinoid X receptor alpha |
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| Synonyms: | Retinoic acid receptor RXR-alpha |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51273.78 |
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| Organism: | RAT |
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| Description: | NR2B Channel Blocker 0 RAT::Q05343 |
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| Residue: | 467 |
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| Sequence: | MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNG
VLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
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| BDBM50445062 |
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| Name | BDBM50445062 |
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| Synonyms: | CHEMBL3098771 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22O2 |
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| Mol. Mass. | 294.3875 |
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| SMILES | C/C(/C=C/C=C(/C)\C=C1/CCCc2ccccc12)=C\C(O)=O |
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| Structure |  |
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| n/a |
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