Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50018005
Substrate
n/a
Meas. Tech.
ChEMBL_1365628
EC50
620±n/a nM
Citation
 Atigadda, VRXia, GDesphande, ABoerma, LJLobo-Ruppert, SGrubbs, CJSmith, CDBrouillette, WJMuccio, DD Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J Med Chem 57:5370-80 (2014) [PubMed]  Article
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50018005
Synonyms:
CHEMBL3289660
Type:
Small organic molecule
Emp. Form.:
C21H24O2
Mol. Mass.:
308.4141
SMILES:
C/C(/C=C/C=C(/C)\C=C1/CCCc2cccc(C)c12)=C\C(O)=O
Structure:
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