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TargetDihydroorotate dehydrogenase
LigandBDBM28817
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1366447
IC50>100000±n/a nM
Citation Deng, XKokkonda, SEl Mazouni, FWhite, JBurrows, JNKaminsky, WCharman, SAMatthews, DRathod, PKPhillips, MA Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem57:5381-94 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase
Name:Dihydroorotate dehydrogenase
Synonyms:DHOdehase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH)
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM28817
NameBDBM28817
Synonyms:5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | DSM74 | triazolopyrimidine-based compound, DSM74
TypeSmall organic molecule
Emp. Form.C13H10F3N5
Mol. Mass.293.2472
SMILESCc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1
Structure
n/a