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TargetDihydroorotate dehydrogenase
LigandBDBM28817
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1366444
IC50>100000±n/a nM
Citation Deng, XKokkonda, SEl Mazouni, FWhite, JBurrows, JNKaminsky, WCharman, SAMatthews, DRathod, PKPhillips, MA Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem57:5381-94 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase
Name:Dihydroorotate dehydrogenase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:42711.08
Organism:Mus musculus
Description:ChEMBL_1366444
Residue:395
Sequence:
MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM28817
NameBDBM28817
Synonyms:5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | DSM74 | triazolopyrimidine-based compound, DSM74
TypeSmall organic molecule
Emp. Form.C13H10F3N5
Mol. Mass.293.2472
SMILESCc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1
Structure
n/a