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TargetSphingosine-1-phosphate lyase 1
LigandBDBM50018270
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1361381
IC50>100000±n/a nM
Citation Weiler, SBraendlin, NBeerli, CBergsdorf, CSchubart, ASrinivas, HOberhauser, BBillich, A Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J Med Chem57:5074-84 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine-1-phosphate lyase 1
Name:Sphingosine-1-phosphate lyase 1
Synonyms:KIAA1252 | S1PL | SGPL1 | SP-lyase 1 | SPL 1 | Sphingosine-1-phosphate aldolase | hSPL
Type:PROTEIN
Mol. Mass.:63546.76
Organism:Homo sapiens (Human)
Description:ChEMBL_108363
Residue:568
Sequence:
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50018270
NameBDBM50018270
Synonyms:CHEMBL1852164
TypeSmall organic molecule
Emp. Form.C9H15N3O5
Mol. Mass.245.2325
SMILESC\C(=N/O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a