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Target
P2Y purinoceptor 11
Ligand
BDBM50019292
Substrate
n/a
Meas. Tech.
ChEMBL_1362532 (CHEMBL3293346)
EC50
900±n/a nM
Citation
 Nadel, Y; Lecka, J; Gilad, Y; Ben-David, G; Förster, D; Reiser, G; Kenigsberg, S; Camden, J; Weisman, GA; Senderowitz, H; Sévigny, J; Fischer, B Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(a or¿)-thio-(a,ß- orß,¿)-methylenetriphosphate scaffold. J Med Chem 57:4677-91 (2014) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 11
Synonyms:
P2RY11 | P2Y purinoceptor 11 | P2Y11 | P2Y11_HUMAN | Purinergic receptor P2Y11
Type:
PROTEIN
Mol. Mass.:
40366.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1362532
Residue:
374
Sequence:
MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ
  
Inhibitor
Name:
BDBM50019292
Synonyms:
CHEMBL3289393
Type:
Small organic molecule
Emp. Form.:
C11H18N5O11P3S
Mol. Mass.:
521.274
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=S)OP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
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