Reaction Details Report a problem with these data
Target
Neurotensin receptor type 2
Ligand
BDBM50019405
Substrate
n/a
Meas. Tech.
ChEMBL_1364514 (CHEMBL3295311)
EC50
28±n/a nM
Citation
 Thomas, JB; Giddings, AM; Wiethe, RW; Olepu, S; Warner, KR; Sarret, P; Gendron, L; Longpre, JM; Zhang, Y; Runyon, SP; Gilmour, BP Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J Med Chem 57:5318-32 (2014) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 2
Synonyms:
High-affinity levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2_RAT | Neurotensin receptor 2 | Neurotensin receptor type 2 | Ntr2 | Ntsr2
Type:
PROTEIN
Mol. Mass.:
46280.50
Organism:
Rattus norvegicus
Description:
ChEMBL_1466615
Residue:
416
Sequence:
METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
  
Inhibitor
Name:
BDBM50019405
Synonyms:
LEVOCABASTINE | R-50547
Type:
Small organic molecule
Emp. Form.:
C26H29FN2O2
Mol. Mass.:
420.5191
SMILES:
C[C@@H]1CN(CC[C@]1(C(O)=O)c1ccccc1)[C@H]1CC[C@](CC1)(C#N)c1ccc(F)cc1 |wU:6.7,16.17,19.24,wD:1.0,6.10,19.26,(9.61,3.85,;8.28,3.08,;8.28,1.54,;6.95,.77,;5.61,1.54,;5.61,3.08,;6.95,3.85,;7.67,5.21,;9.21,5.26,;7.78,6.75,;6.22,5.21,;4.68,5.26,;3.96,6.62,;4.78,7.93,;6.32,7.88,;7.04,6.52,;6.95,-.77,;8.28,-1.54,;8.28,-3.08,;6.95,-3.85,;5.61,-3.08,;5.61,-1.54,;6.22,-5.21,;5.5,-6.57,;7.67,-5.21,;9.21,-5.26,;9.93,-6.62,;9.11,-7.93,;9.84,-9.29,;7.57,-7.88,;6.85,-6.52,)|
Structure:
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