Reaction Details Report a problem with these data
Target
Neurotensin receptor type 2
Ligand
BDBM50019409
Substrate
n/a
Meas. Tech.
ChEMBL_1364514 (CHEMBL3295311)
EC50
166±n/a nM
Citation
 Thomas, JB; Giddings, AM; Wiethe, RW; Olepu, S; Warner, KR; Sarret, P; Gendron, L; Longpre, JM; Zhang, Y; Runyon, SP; Gilmour, BP Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J Med Chem 57:5318-32 (2014) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 2
Synonyms:
High-affinity levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2_RAT | Neurotensin receptor 2 | Neurotensin receptor type 2 | Ntr2 | Ntsr2
Type:
PROTEIN
Mol. Mass.:
46280.50
Organism:
Rattus norvegicus
Description:
ChEMBL_1466615
Residue:
416
Sequence:
METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
  
Inhibitor
Name:
BDBM50019409
Synonyms:
CHEMBL3290093
Type:
Small organic molecule
Emp. Form.:
C27H23ClF2N4O3
Mol. Mass.:
524.946
SMILES:
OC(=O)[C@@H](NC(=O)c1cc(-c2c(F)cccc2F)n(n1)-c1ccnc2cc(Cl)ccc12)C1CCCCC1 |r,wU:3.34,(22.59,-5.16,;22.75,-6.7,;24.15,-7.32,;21.5,-7.6,;21.66,-9.13,;23.07,-9.76,;24.32,-8.85,;23.23,-11.29,;24.56,-12.06,;24.24,-13.57,;25.58,-15.05,;25.11,-16.52,;23.6,-16.84,;26.14,-17.66,;27.64,-17.34,;28.12,-15.88,;27.09,-14.73,;27.57,-13.27,;22.71,-13.73,;22.09,-12.32,;21.94,-15.06,;22.71,-16.39,;21.94,-17.73,;20.4,-17.73,;19.63,-16.39,;18.09,-16.39,;17.32,-15.06,;15.78,-15.06,;18.09,-13.73,;19.63,-13.73,;20.4,-15.06,;20.09,-6.97,;18.85,-7.88,;17.44,-7.25,;17.28,-5.72,;18.53,-4.82,;19.93,-5.44,)|
Structure:
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