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TargetCytochrome P450 11B2, mitochondrial
LigandBDBM50444549
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1361874
IC50 0.200000±n/a nM
Citation Yin, LHu, QEmmerich, JLo, MMMetzger, EAli, AHartmann, RW Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J Med Chem57:5179-89 (2014) [PubMed]  Article
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Cytochrome P450 11B2, mitochondrial
Name:Cytochrome P450 11B2, mitochondrial
Synonyms:Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:Enzyme
Mol. Mass.:57582.15
Organism:Homo sapiens (human)
Description:n/a
Residue:503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM50444549
NameBDBM50444549
Synonyms:CHEMBL3099695
TypeSmall organic molecule
Emp. Form.C13H10FN3
Mol. Mass.227.237
SMILESFc1cc(ccc1[C@H]1CCc2cncn12)C#N |r|
Structure
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n/a