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TargetAdrenergic beta-2 receptor (beta2)
LigandBDBM50021866
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1369174
Ki 1.3±n/a nM
Citation McKinnell, RMKlein, ULinsell, MSMoran, EJNodwell, MBPfeiffer, JWThomas, GRYu, CJacobsen, JR Discovery of TD-4306, a long-acting▀2-agonist for the treatment of asthma and COPD. Bioorg Med Chem Lett24:2871-6 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adrenergic beta-2 receptor (beta2)
Name:Adrenergic beta-2 receptor (beta2)
Synonyms:ADRB2 | ADRB2R | ADRB2R, B2AR | B2AR | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:n/a
Mol. Mass.:46461.69
Organism:Homo sapiens (Human)
Description:n/a
Residue:413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50021866
NameBDBM50021866
Synonyms:CHEMBL3298326
TypeSmall organic molecule
Emp. Form.C33H34N4O4
Mol. Mass.550.6475
SMILESCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a