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Target
Serine/threonine-protein kinase 17A
Ligand
BDBM50024284
Substrate
n/a
Meas. Tech.
ChEMBL_1435939 (CHEMBL3382249)
IC50
630±n/a nM
Citation
 Gao, LJ; Kovackova, S; Sála, M; Ramadori, AT; De Jonghe, S; Herdewijn, P Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach. J Med Chem 57:7624-43 (2014) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 17A
Synonyms:
DRAK1 | ST17A_HUMAN | STK17A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46544.04
Organism:
Homo sapiens (Human)
Description:
gi_109255245
Residue:
414
Sequence:
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
  
Inhibitor
Name:
BDBM50024284
Synonyms:
CHEMBL3334979
Type:
Small organic molecule
Emp. Form.:
C22H24N2O3S
Mol. Mass.:
396.503
SMILES:
COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Structure:
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