Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50026819
Substrate
n/a
Meas. Tech.
ChEMBL_1438220 (CHEMBL3390252)
Ki
1960±n/a nM
Citation
 Moss, SM; Jayasekara, PS; Paoletta, S; Gao, ZG; Jacobson, KA Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor. ACS Med Chem Lett 5:1043-8 (2014) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50026819
Synonyms:
CHEMBL3335525
Type:
Small organic molecule
Emp. Form.:
C39H47N11O10S
Mol. Mass.:
861.923
SMILES:
[H][C@]12CS[C@@H](CCCCC(=O)Oc3ccc(NC(=O)CCc4ccc(CCNc5nc(N)c6ncn([C@@H]7O[C@@H]([C@@H](O)[C@H]7O)C(=O)NCC)c6n5)cc4)cc3[N+]([O-])=O)[C@@]1([H])NC(=O)N2 |r|
Structure:
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