Reaction Details Report a problem with these data
Target
Sortase family protein
Ligand
BDBM50201782
Substrate
n/a
Meas. Tech.
ChEMBL_1431503 (CHEMBL3389868)
IC50
16910±n/a nM
Citation
 Zhulenkovs, D; Rudevica, Z; Jaudzems, K; Turks, M; Leonchiks, A Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase. Bioorg Med Chem 22:5988-6003 (2014) [PubMed]  Article 
Target
Name:
Sortase family protein
Synonyms:
Sortase | Sortase A (SrtA)
Type:
Enzyme
Mol. Mass.:
23546.15
Organism:
Staphylococcus aureus
Description:
n/a
Residue:
206
Sequence:
MKKWTNRLMTIAGVVLILVAAYLFAKPHIDNYLHDKDKDEKIEQYDKNVKEQASKDKKQQAKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENESLDDQNISIAGHTFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSIRDVKPTDVGVLDEQKGKDKQLTLITCDDYNEKTGVWEKRKIFVATEVK
  
Inhibitor
Name:
BDBM50201782
Synonyms:
1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride | CHEMBL264166 | CHEMBL536752
Type:
Small organic molecule
Emp. Form.:
C11H13Cl2NO
Mol. Mass.:
246.133
SMILES:
CN(C)CCC(=O)c1ccc(Cl)c(Cl)c1
Structure:
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