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Target
Procathepsin L
Ligand
BDBM50030747
Substrate
n/a
Meas. Tech.
ChEMBL_1437727 (CHEMBL3382374)
Ki
573±n/a nM
Citation
 Schmitz, J; Beckmann, AM; Dudic, A; Li, T; Sellier, R; Bartz, U; Gütschow, M 3-Cyano-3-aza-ß-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins. ACS Med Chem Lett 5:1076-81 (2014) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50030747
Synonyms:
CHEMBL3342183
Type:
Small organic molecule
Emp. Form.:
C12H20N4O4
Mol. Mass.:
284.3116
SMILES:
CC(C)(C)OC(=O)NN(CC(=O)N1CCOCC1)C#N
Structure:
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