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Target
Peptidase 1
Ligand
BDBM50031699
Substrate
n/a
Meas. Tech.
ChEMBL_1443313 (CHEMBL3374743)
IC50
14±n/a nM
Citation
 Newton, GK; Perrior, TR; Jenkins, K; Major, MR; Key, RE; Stewart, MR; Firth-Clark, S; Lloyd, SM; Zhang, J; Francis-Newton, NJ; Richardson, JP; Chen, J; Lai, P; Garrod, DR; Robinson, C The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. J Med Chem 57:9447-62 (2014) [PubMed]  Article 
Target
Name:
Peptidase 1
Synonyms:
DERP1 | PEPT1_DERPT | Peptidase 1 (Der p 1)
Type:
Enzyme
Mol. Mass.:
36101.04
Organism:
Dermatophagoides pteronyssinus (European house dust mite)
Description:
P08176
Residue:
320
Sequence:
MKIVLAIASLLALSAVYARPSSIKTFEEYKKAFNKSYATFEDEEAARKNFLESVKYVQSNGGAINHLSDLSLDEFKNRFLMSAEAFEHLKTQFDLNAETNACSINGNAPAEIDLRQMRTVTPIRMQGGCGSCWAFSGVAATESAYLAYRNQSLDLAEQELVDCASQHGCHGDTIPRGIEYIQHNGVVQESYYRYVAREQSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAVIIGIKDLDAFRHYDGRTIIQRDNGYQPNYHAVNIVGYSNAQGVDYWIVRNSWDTNWGDNGYGYFAANIDLMMIEEYPYVVIL
  
Inhibitor
Name:
BDBM50031699
Synonyms:
CHEMBL3360288
Type:
Small organic molecule
Emp. Form.:
C32H42N6O6
Mol. Mass.:
606.7125
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NCC(=O)N1CCN(C)CC1 |r|
Structure:
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