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TargetCathepsin (B and K)
LigandBDBM50031689
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1443314
IC50>2500±n/a nM
Citation Newton, GKPerrior, TRJenkins, KMajor, MRKey, REStewart, MRFirth-Clark, SLloyd, SMZhang, JFrancis-Newton, NJRichardson, JPChen, JLai, PGarrod, DRRobinson, C The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. J Med Chem57:9447-62 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin (B and K)
Name:Cathepsin (B and K)
Synonyms:APP secretase | APPS | Cathepsin B | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:Enzyme
Mol. Mass.:37819.69
Organism:Homo sapiens (Human)
Description:gi_63102437
Residue:339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50031689
NameBDBM50031689
Synonyms:CHEMBL3360298
TypeSmall organic molecule
Emp. Form.C34H49N7O6
Mol. Mass.651.7962
SMILESCC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccnc2ccccc12)C(C)(C)C)C(=O)C(=O)NCC(=O)N1CCN(CC1)C(C)C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a