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Target
Neutrophil elastase
Ligand
BDBM50032888
Substrate
n/a
Meas. Tech.
ChEMBL_1431796 (CHEMBL3385092)
EC50
4.0±n/a nM
Citation
 Abdel-Magid, AF Neutrophil elastase inhibitors as potential anti-inflammatory therapies. ACS Med Chem Lett 5:1182-3 (2014) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50032888
Synonyms:
CHEMBL3342778 | US9290459, 6.3 | US9670166, 6.3
Type:
Small organic molecule
Emp. Form.:
C26H21F3N4O3
Mol. Mass.:
494.4651
SMILES:
FC(F)(F)c1cccc(c1)N1C2=C(C(N(CC(=O)N3CCC3)C1=O)c1ccc(cc1)C#N)C(=O)CC2 |c:12|
Structure:
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