Reaction Details Report a problem with these data
Target
Reverse transcriptase
Ligand
BDBM1434
Substrate
n/a
Meas. Tech.
ChEMBL_1435799 (CHEMBL3389554)
IC50
9000±n/a nM
Citation
Famiglini, V; La Regina, G; Coluccia, A; Pelliccia, S; Brancale, A; Maga, G; Crespan, E; Badia, R; Riveira-Muñoz, E; Esté, JA; Ferretti, R; Cirilli, R; Zamperini, C; Botta, M; Schols, D; Limongelli, V; Agostino, B; Novellino, E; Silvestri, R Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors. J Med Chem 57:9945-57 (2014) [PubMed] Article
More Info.:
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
Inhibitor
Name:
BDBM1434
Synonyms:
11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2 ,3 -e][1,4]diazepin-6-one | 2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one | BI-RG-587 | CHEMBL57 | Nevirapine | Nevirapine (NVP) | US11420959, Example NVP | Viramune
Type:
Small organic molecule
Emp. Form.:
C15H14N4O
Mol. Mass.:
266.2979
SMILES:
Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12