Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50034103
Substrate
n/a
Meas. Tech.
ChEMBL_1437207 (CHEMBL3382981)
Ki
422±n/a nM
Citation
 Lan, Y; Chen, Y; Cao, X; Zhang, J; Wang, J; Xu, X; Qiu, Y; Zhang, T; Liu, X; Liu, BF; Zhang, G Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem 57:10404-23 (2014) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50034103
Synonyms:
CHEMBL3358639
Type:
Small organic molecule
Emp. Form.:
C19H25N3O3
Mol. Mass.:
343.4201
SMILES:
Cc1cc(OCCOCCN2CCOCC2)nc(n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: