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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50034790
Substrate
n/a
Meas. Tech.
ChEMBL_1441019 (CHEMBL3377015)
EC50
20±n/a nM
Citation
 Kick, E; Martin, R; Xie, Y; Flatt, B; Schweiger, E; Wang, TL; Busch, B; Nyman, M; Gu, XH; Yan, G; Wagner, B; Nanao, M; Nguyen, L; Stout, T; Plonowski, A; Schulman, I; Ostrowski, J; Kirchgessner, T; Wexler, R; Mohan, R Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß. Bioorg Med Chem Lett 25:372-7 (2014) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50034790
Synonyms:
CHEMBL3360961
Type:
Small organic molecule
Emp. Form.:
C26H15F5N2O2
Mol. Mass.:
482.4015
SMILES:
Fc1ccc(Cn2c(cc(c(C#N)c2=O)C(F)(F)F)-c2ccc(Oc3ccccc3)cc2)c(F)c1
Structure:
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