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Target
Nuclear receptor ROR-beta
Ligand
BDBM50035907
Substrate
n/a
Meas. Tech.
ChEMBL_1431073 (CHEMBL3383189)
EC50
3800±n/a nM
Citation
 van Niel, MB; Fauber, BP; Cartwright, M; Gaines, S; Killen, JC; René, O; Ward, SI; de Leon Boenig, G; Deng, Y; Eidenschenk, C; Everett, C; Gancia, E; Ganguli, A; Gobbi, A; Hawkins, J; Johnson, AR; Kiefer, JR; La, H; Lockey, P; Norman, M; Ouyang, W; Qin, A; Wakes, N; Waszkowycz, B; Wong, H A reversed sulfonamide series of selective RORc inverse agonists. Bioorg Med Chem Lett 24:5769-76 (2014) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta
Type:
PROTEIN
Mol. Mass.:
53227.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107979
Residue:
470
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM50035907
Synonyms:
CHEMBL3361050
Type:
Small organic molecule
Emp. Form.:
C24H32F3N3O4S2
Mol. Mass.:
547.654
SMILES:
CC(C)CN(Cc1ccccc1C(F)(F)F)S(=O)(=O)c1ccc(NC2CCN(CC2)S(C)(=O)=O)cc1
Structure:
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