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Target
Acid ceramidase
Ligand
BDBM50392472
Substrate
n/a
Meas. Tech.
ChEMBL_1435908 (CHEMBL3381632)
IC50
27700±n/a nM
Citation
 Bai, A; Szulc, ZM; Bielawski, J; Pierce, JS; Rembiesa, B; Terzieva, S; Mao, C; Xu, R; Wu, B; Clarke, CJ; Newcomb, B; Liu, X; Norris, J; Hannun, YA; Bielawska, A Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem 22:6933-44 (2014) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50392472
Synonyms:
CHEMBL408217
Type:
Small organic molecule
Emp. Form.:
C23H38N2O5
Mol. Mass.:
422.5582
SMILES:
CCCCCCCCCCCCCC(=O)N[C@H](CO)[C@H](O)c1ccc(cc1)[N+]([O-])=O |r|
Structure:
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