Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50038360
Substrate
n/a
Meas. Tech.
ChEMBL_1441163 (CHEMBL3378827)
Ki
8.4±n/a nM
Citation
 Donnier-Maréchal, M; Larchanché, PE; Le Broc, D; Furman, C; Carato, P; Melnyk, P Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands. Eur J Med Chem 89:198-206 (2014) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50038360
Synonyms:
CHEMBL3360570
Type:
Small organic molecule
Emp. Form.:
C28H29N3
Mol. Mass.:
407.55
SMILES:
C(CN1Cc2ccccc2C1)CN1CCc2c([nH]c3ccccc23)C1c1ccccc1
Structure:
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