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Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50040478
Substrate
n/a
Meas. Tech.
ChEMBL_1443968 (CHEMBL3375356)
IC50
2500±n/a nM
Citation
 Sun, Z; Khan, J; Makowska-Grzyska, M; Zhang, M; Cho, JH; Suebsuwong, C; Vo, P; Gollapalli, DR; Kim, Y; Joachimiak, A; Hedstrom, L; Cuny, GD Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. J Med Chem 57:10544-50 (2014) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43076.80
Organism:
Cryptosporidium parvum
Description:
Q8T6T2
Residue:
400
Sequence:
MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM50040478
Synonyms:
CHEMBL3360630
Type:
Small organic molecule
Emp. Form.:
C20H17N3O5
Mol. Mass.:
379.3661
SMILES:
COc1ccc(NC(=O)Cn2ncc3c2c2ccccc2oc3=O)cc1OC
Structure:
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