Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50040973
Substrate
n/a
Meas. Tech.
ChEMBL_1444771 (CHEMBL3378472)
EC50
>30000±n/a nM
Citation
Han, S; Thoresen, L; Zhu, X; Narayanan, S; Jung, JK; Strah-Pleynet, S; Decaire, M; Choi, K; Xiong, Y; Yue, D; Semple, G; Thatte, J; Solomon, M; Fu, L; Whelan, K; Al-Shamma, H; Gatlin, J; Chen, R; Dang, H; Pride, C; Gaidarov, I; Unett, DJ; Behan, DP; Sadeque, A; Usmani, KA; Chen, C; Edwards, J; Morgan, M; Jones, RM Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists. Bioorg Med Chem Lett 25:322-6 (2014) [PubMed] Article
More Info.:
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Inhibitor
Name:
BDBM50040973
Synonyms:
CHEMBL3354972
Type:
Small organic molecule
Emp. Form.:
C18H19F2N3O2
Mol. Mass.:
347.3592
SMILES:
[H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1c(F)cccc1F)C(=O)NC(C)(C)CO |r,wU:1.0,3.4,(21.92,-31.59,;21.53,-33.09,;20.13,-32.44,;20.27,-33.98,;18.93,-33.2,;20.73,-35.45,;22.27,-35.46,;22.76,-34,;22.73,-36.93,;21.48,-37.82,;20.24,-36.9,;18.7,-36.94,;17.97,-38.29,;18.78,-39.6,;16.43,-38.33,;15.62,-37.01,;16.36,-35.65,;17.9,-35.62,;18.65,-34.27,;24.07,-37.69,;24.09,-39.23,;25.4,-36.9,;26.74,-37.66,;27.51,-38.99,;25.97,-38.98,;28.08,-36.88,;29.41,-37.65,)|