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Target
Bombesin receptor subtype-3
Ligand
BDBM50447492
Substrate
n/a
Meas. Tech.
ChEMBL_1445901 (CHEMBL3377328)
EC50
9.5±n/a nM
Citation
 Matsufuji, T; Shimada, K; Kobayashi, S; Ichikawa, M; Kawamura, A; Fujimoto, T; Arita, T; Hara, T; Konishi, M; Abe-Ohya, R; Izumi, M; Sogawa, Y; Nagai, Y; Yoshida, K; Abe, Y; Kimura, T; Takahashi, H Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach. Bioorg Med Chem 23:89-104 (2014) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50447492
Synonyms:
CHEMBL3115373
Type:
Small organic molecule
Emp. Form.:
C23H21F3N4O2
Mol. Mass.:
442.4336
SMILES:
Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)cn1
Structure:
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