Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50042862
Substrate
n/a
Meas. Tech.
ChEMBL_1444649 (CHEMBL3376647)
IC50
360±n/a nM
Citation
 Ishchenko, A; Zhang, L; Le Brazidec, JY; Fan, J; Chong, JH; Hingway, A; Raditsis, A; Singh, L; Elenbaas, B; Hong, VS; Marcotte, D; Silvian, L; Enyedy, I; Chao, J Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg Med Chem Lett 25:474-80 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50042862
Synonyms:
CHEMBL3354512
Type:
Small organic molecule
Emp. Form.:
C19H16F2N4O2S
Mol. Mass.:
402.418
SMILES:
Fc1cccc(F)c1-c1nc(cs1)C(=O)Nc1cnccc1O[C@@H]1CCNC1 |r|
Structure:
Search PDB for entries with ligand similarity: