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Target
Wee1-like protein kinase
Ligand
BDBM50043644
Substrate
n/a
Meas. Tech.
ChEMBL_1445052 (CHEMBL3372984)
Ki
8.6±n/a nM
Citation
 Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett 6:58-62 (2015) [PubMed]  Article 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM50043644
Synonyms:
CHEMBL3355529
Type:
Small organic molecule
Emp. Form.:
C24H20ClN7O
Mol. Mass.:
457.915
SMILES:
CN1CCCc2ccc(Nc3ncc4c(n3)n3ccnc3n(-c3ccccc3Cl)c4=O)cc12 |(27.6,-44.19,;26.26,-44.96,;26.25,-46.5,;24.92,-47.27,;23.59,-46.49,;23.59,-44.96,;22.26,-44.19,;22.26,-42.65,;23.6,-41.89,;23.6,-40.35,;22.27,-39.57,;22.27,-38.03,;20.94,-37.26,;19.61,-38.02,;19.6,-39.56,;20.93,-40.34,;18.27,-40.33,;17.95,-41.82,;16.43,-41.97,;15.82,-40.58,;16.96,-39.56,;16.95,-38.01,;15.62,-37.25,;14.28,-38.02,;12.95,-37.25,;12.95,-35.7,;14.28,-34.93,;15.61,-35.7,;16.94,-34.92,;18.28,-37.25,;18.28,-35.71,;24.93,-42.65,;24.93,-44.19,)|
Structure:
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