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Target
Transcription factor Jun
Ligand
BDBM50090430
Substrate
n/a
Meas. Tech.
ChEMBL_1457997 (CHEMBL3367171)
IC50
20±n/a nM
Citation
 Ye, N; Ding, Y; Wild, C; Shen, Q; Zhou, J Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem 57:6930-48 (2014) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50090430
Synonyms:
4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino)-2-thiophen-2-yl-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL43549 | ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(thiophen-2-yl)pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H14N4O4S
Mol. Mass.:
358.372
SMILES:
CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1cccs1 |t:16|
Structure:
Search PDB for entries with ligand similarity: