Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50045456
Substrate
n/a
Meas. Tech.
ChEMBL_1459867 (CHEMBL3367290)
Ki
67110±n/a nM
Citation
 Raghav, N; Singh, M SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H. Bioorg Med Chem 22:4233-45 (2014) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
36777.57
Organism:
Capra hircus (Goat)
Description:
n/a
Residue:
335
Sequence:
MWQLLATLSCLLVLTSARSSLHFPPLSDEMVNYVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADMVLPDSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSKGRVNVEVSAEDMLTCCGSECGDGCNGGFPSGAWNFWTKKGLVSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPSYKDDKHFGCSSYSVSSNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEMMGGHAIRILGWGVENDTPYWLVGNSWNTDWGDKGFFKILRGQDHCGIESEIVAGMPCTHQY
  
Inhibitor
Name:
BDBM50045456
Synonyms:
CHEMBL1209128
Type:
Small organic molecule
Emp. Form.:
C17H15BrN2O
Mol. Mass.:
343.218
SMILES:
CC(=O)N1N=C(CC1c1ccc(Br)cc1)c1ccccc1 |c:4|
Structure:
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