Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50049514
Substrate
n/a
Meas. Tech.
ChEMBL_1450310 (CHEMBL3377547)
Ki
5.9±n/a nM
Citation
 Ceruso, M; Del Prete, S; AlOthman, Z; Osman, SM; Scozzafava, A; Capasso, C; Supuran, CT Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis¿-carbonic anhydrase. Bioorg Med Chem Lett 24:4006-10 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50049514
Synonyms:
CHEMBL3314183
Type:
Small organic molecule
Emp. Form.:
C15H23N3O5S
Mol. Mass.:
357.425
SMILES:
CC(C)(C)OC(=O)NCCCC(=O)Nc1cccc(c1)S(N)(=O)=O
Structure:
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