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Target
Sodium- and chloride-dependent betaine transporter
Ligand
BDBM50051038
Substrate
n/a
Meas. Tech.
ChEMBL_1460088 (CHEMBL3368848)
IC50
20417±n/a nM
Citation
 Quandt, G; Höfner, G; Pabel, J; Dine, J; Eder, M; Wanner, KT First photoswitchable neurotransmitter transporter inhibitor: light-induced control of¿-aminobutyric acid transporter 1 (GAT1) activity in mouse brain. J Med Chem 57:6809-21 (2014) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent betaine transporter
Synonyms:
GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12
Type:
PROTEIN
Mol. Mass.:
69615.88
Organism:
Mus musculus
Description:
ChEMBL_1460088
Residue:
614
Sequence:
MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGRRDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSPAKQELIAWEKETHL
  
Inhibitor
Name:
BDBM50051038
Synonyms:
CHEMBL3318047
Type:
Small organic molecule
Emp. Form.:
C26H29N3O3
Mol. Mass.:
431.5268
SMILES:
OC(=O)[C@@H]1CCCN(CCOCCc2ccc(cc2)\N=N\c2cccc3ccccc23)C1 |r|
Structure:
Search PDB for entries with ligand similarity: