Target
L-lactate dehydrogenase A chain
Ligand
BDBM50052259
Substrate
n/a
Meas. Tech.
ChEMBL_1456605 (CHEMBL3369987)
Kd
500±n/a nM
Citation
 Dragovich, PSFauber, BPBoggs, JChen, JCorson, LBDing, CZEigenbrot, CGe, HGiannetti, AMHunsaker, TLabadie, SLi, CLiu, YLiu, YMa, SMalek, SPeterson, DPitts, KEPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWang, JWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett 24:3764-71 (2014) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50052259
Synonyms:
CHEMBL3318472
Type:
Small organic molecule
Emp. Form.:
C19H13Cl2F3O2S
Mol. Mass.:
433.272
SMILES:
OC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1c(Cl)cccc1C(F)(F)F |c:1|
Structure:
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