Target
L-lactate dehydrogenase A chain
Ligand
BDBM50052400
Substrate
n/a
Meas. Tech.
ChEMBL_1456602 (CHEMBL3369984)
IC50
>100000±n/a nM
Citation
 Dragovich, PSFauber, BPBoggs, JChen, JCorson, LBDing, CZEigenbrot, CGe, HGiannetti, AMHunsaker, TLabadie, SLi, CLiu, YLiu, YMa, SMalek, SPeterson, DPitts, KEPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWang, JWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett 24:3764-71 (2014) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50052400
Synonyms:
CHEMBL3318475
Type:
Small organic molecule
Emp. Form.:
C20H19ClO2S
Mol. Mass.:
358.882
SMILES:
Cc1cccc(C)c1C1CC(O)=C(Sc2ccccc2Cl)C(=O)C1 |t:12|
Structure:
Search PDB for entries with ligand similarity: