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Target
Somatostatin receptor type 3
Ligand
BDBM50054507
Substrate
n/a
Meas. Tech.
ChEMBL_1447895 (CHEMBL3378642)
IC50
8.4±n/a nM
Citation
 He, S; Lai, Z; Ye, Z; Dobbelaar, PH; Shah, SK; Truong, Q; Du, W; Guo, L; Liu, J; Jian, T; Qi, H; Bakshi, RK; Hong, Q; Dellureficio, J; Reibarkh, M; Samuel, K; Reddy, VB; Mitelman, S; Tong, SX; Chicchi, GG; Tsao, KL; Trusca, D; Wu, M; Shao, Q; Trujillo, ME; Fernandez, G; Nelson, D; Bunting, P; Kerr, J; Fitzgerald, P; Morissette, P; Volksdorf, S; Eiermann, GJ; Li, C; Zhang, B; Howard, AD; Zhou, YP; Nargund, RP; Hagmann, WK Investigation of Cardiovascular Effects of Tetrahydro-ß-carboline sstr3 antagonists. ACS Med Chem Lett 5:748-53 (2014) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SS3R | SSR-28 | SSR3_MOUSE | Smstr3 | Somatostatin receptor | Somatostatin receptor 3 | Somatostatin receptor type 3 | Sstr3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47225.49
Organism:
MOUSE
Description:
SOMATOSTATIN SST3 SSTR3 MOUSE::P30935
Residue:
428
Sequence:
MATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQAGTSGQQPRPCTGTAKEQQLLPQEATAGDKASTLSHL
  
Inhibitor
Name:
BDBM50054507
Synonyms:
CHEMBL3323077
Type:
Small organic molecule
Emp. Form.:
C32H28FN7O2
Mol. Mass.:
561.6088
SMILES:
CCOC(=O)c1cncc(c1)[C@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cc1)c1cnn(C)c1 |r|
Structure:
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