Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50055098
Substrate
n/a
Meas. Tech.
ChEMBL_1447963 (CHEMBL3379789)
IC50
247±n/a nM
Citation
 Squarcialupi, L; Colotta, V; Catarzi, D; Varano, F; Betti, M; Varani, K; Vincenzi, F; Borea, PA; Porta, N; Ciancetta, A; Moro, S 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies. Eur J Med Chem 84:614-27 (2014) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50055098
Synonyms:
CHEMBL3317578
Type:
Small organic molecule
Emp. Form.:
C20H19N5O
Mol. Mass.:
345.3978
SMILES:
Nc1nc(CCCc2ccccc2O)nc2cn(nc12)-c1ccccc1
Structure:
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