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Target
Beta-2 adrenergic receptor
Ligand
BDBM50055252
Substrate
n/a
Meas. Tech.
ChEMBL_1449714 (CHEMBL3378137)
Ki
4.2±n/a nM
Citation
 Arnold, N; Beattie, D; Bradley, M; Brearley, A; Brown, L; Charlton, SJ; Fairhurst, RA; Farr, D; Fozard, J; Fullerton, J; Gosling, M; Hatto, J; Janus, D; Jones, D; Jordan, L; Lewis, C; Maas, J; McCarthy, C; Mercer, M; Oakman, H; Press, N; Profit, R; Schuerch, F; Sykes, D; Taylor, RJ; Trifilieff, A; Tuffnell, A The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-actingß2-adrenoceptor agonist. Bioorg Med Chem Lett 24:4341-7 (2014) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50055252
Synonyms:
CHEMBL3323657
Type:
Small organic molecule
Emp. Form.:
C17H24N2O3S
Mol. Mass.:
336.449
SMILES:
CC(C)[C@H]1CCC[C@H]1NC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12 |r|
Structure:
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