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TargetAdrenergic beta-2 receptor (beta2)
LigandBDBM50055263
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1449714
Ki 0.600000±n/a nM
Citation Arnold, NBeattie, DBradley, MBrearley, ABrown, LCharlton, SJFairhurst, RAFarr, DFozard, JFullerton, JGosling, MHatto, JJanus, DJones, DJordan, LLewis, CMaas, JMcCarthy, CMercer, MOakman, HPress, NProfit, RSchuerch, FSykes, DTaylor, RJTrifilieff, ATuffnell, A The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting▀2-adrenoceptor agonist. Bioorg Med Chem Lett24:4341-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adrenergic beta-2 receptor (beta2)
Name:Adrenergic beta-2 receptor (beta2)
Synonyms:ADRB2 | ADRB2R | ADRB2R, B2AR | B2AR | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor | adrenergic Beta | adrenergic Beta2
Type:n/a
Mol. Mass.:46461.69
Organism:Homo sapiens (Human)
Description:n/a
Residue:413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50055263
NameBDBM50055263
Synonyms:CHEMBL3323654
TypeSmall organic molecule
Emp. Form.C19H26N2O3S
Mol. Mass.362.486
SMILESO[C@@H](CN[C@H]1CCC[C@@H]1C1CCCC1)c1ccc(O)c2[nH]c(=O)sc12 |r|
Structure
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n/a