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TargetPresenilin-1
LigandBDBM50062726
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1462966
EC50 1100±n/a nM
Citation Flesch, DNess, JLamers, CDehm, FPopella, SSteri, ROgorek, IHieke, MDannhardt, GWerz, OWeggen, SSchubert-Zsilavecz, M SAR-studies of┐-secretase modulators with PPAR┐-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. Bioorg Med Chem Lett25:841-6 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Presenilin-1
Name:Presenilin-1
Synonyms:3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:n/a
Mol. Mass.:52657.13
Organism:Homo sapiens (Human)
Description:P49768
Residue:467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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  Blast E-value cutoff:
BDBM50062726
n/a
NameBDBM50062726
Synonyms:CHEMBL3397727
TypeSmall organic molecule
Emp. Form.C29H32F6O4
Mol. Mass.558.5524
SMILESCCCC\C(=C/c1cc(OCC2CCC(CC2)C(F)(F)F)ccc1OCc1ccc(cc1)C(F)(F)F)C(O)=O |(5.33,-7.4,;5.33,-6.17,;3.99,-5.4,;4,-3.86,;2.66,-3.08,;2.67,-1.54,;4,-.77,;5.33,-1.55,;6.67,-.78,;8,-1.56,;7.99,-3.1,;9.32,-3.88,;9.32,-5.42,;10.65,-6.19,;11.99,-5.42,;11.99,-3.88,;10.66,-3.11,;13.32,-6.2,;13.32,-7.43,;14.39,-5.58,;14.38,-6.82,;6.67,.76,;5.34,1.53,;4.01,.77,;2.68,1.54,;2.68,3.08,;1.35,3.86,;1.36,5.4,;.02,6.17,;-1.31,5.41,;-1.32,3.87,;.02,3.09,;-2.64,6.18,;-2.64,7.41,;-3.71,5.57,;-3.71,6.8,;1.33,-3.85,;1.32,-5.08,;.26,-3.23,)|
Structure
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