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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM50063864
Substrate
n/a
Meas. Tech.
ChEMBL_1463807 (CHEMBL3404970)
EC50
5.8±n/a nM
Citation
 Buzard, DJ; Schrader, TO; Zhu, X; Lehmann, J; Johnson, B; Kasem, M; Kim, SH; Kawasaki, A; Lopez, L; Moody, J; Han, S; Gao, Y; Edwards, J; Barden, J; Thatte, J; Gatlin, J; Jones, RM Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor. Bioorg Med Chem Lett 25:659-63 (2015) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM50063864
Synonyms:
CHEMBL3403619 | US10676467, Compound TZ 50 13
Type:
Small organic molecule
Emp. Form.:
C26H27F3N2O3
Mol. Mass.:
472.4994
SMILES:
OC(=O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21
Structure:
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