Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAdenosine A3 receptor
LigandBDBM50389148
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1469768
Ki 3.1±n/a nM
Citation Tosh, DKFinley, APaoletta, SMoss, SMGao, ZGGizewski, ETAuchampach, JASalvemini, DJacobson, KA In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists. J Med Chem57:9901-14 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine A3 receptor
Name:Adenosine A3 receptor
Synonyms:A3AR | Adenosine receptor A3
Type:PROTEIN
Mol. Mass.:36460.91
Organism:Mus musculus
Description:ChEMBL_1515686
Residue:319
Sequence:
MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADI
AVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYR
TVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVF
FSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLF
ALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRA
VRLCQTSDSLDSNMEQTTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50389148
NameBDBM50389148
Synonyms:CHEMBL2064657
TypeSmall organic molecule
Emp. Form.C28H23ClF2N6O3
Mol. Mass.564.97
SMILESCNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n1cnc2c(NCc3cccc(Cl)c3)nc(nc12)C#Cc1ccc(F)c(F)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a