Reaction Details Report a problem with these data
Target
Pantothenate kinase 3
Ligand
BDBM50071514
Substrate
n/a
Meas. Tech.
ChEMBL_1469804 (CHEMBL3413798)
EC50
1510±n/a nM
Citation
 Sharma, LK; Leonardi, R; Lin, W; Boyd, VA; Goktug, A; Shelat, AA; Chen, T; Jackowski, S; Rock, CO A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem 58:1563-8 (2015) [PubMed]  Article 
Target
Name:
Pantothenate kinase 3
Synonyms:
PANK3 | PANK3_HUMAN | Pantothenate kinase 3 | Pantothenic acid kinase 3 | hPanK3
Type:
PROTEIN
Mol. Mass.:
41093.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109587
Residue:
370
Sequence:
MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS
  
Inhibitor
Name:
BDBM50071514
Synonyms:
CHEMBL3410241
Type:
Small organic molecule
Emp. Form.:
C19H17ClFN3OS
Mol. Mass.:
389.874
SMILES:
Fc1ccc(CC(=O)N2CCN(CC2)c2nc3c(Cl)cccc3s2)cc1
Structure:
Search PDB for entries with ligand similarity: