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Target
Translocator protein
Ligand
BDBM50073599
Substrate
n/a
Meas. Tech.
ChEMBL_1467416 (CHEMBL3411700)
Ki
1.4±n/a nM
Citation
 Banister, SD; Beinat, C; Wilkinson, SM; Shen, B; Bartoli, C; Selleri, S; Da Pozzo, E; Martini, C; Chin, FT; Kassiou, M Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). Eur J Med Chem 93:392-400 (2015) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50073599
Synonyms:
CHEMBL3408970
Type:
Small organic molecule
Emp. Form.:
C28H29F3N4O2
Mol. Mass.:
510.5507
SMILES:
CCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(OCc2ccccc2C(F)(F)F)cc1
Structure:
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