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Target
Transcriptional activator protein LasR
Ligand
BDBM50351506
Substrate
n/a
Meas. Tech.
ChEMBL_1475312 (CHEMBL3425209)
IC50
30000±n/a nM
Citation
 O'Brien, KT; Noto, JG; Nichols-O'Neill, L; Perez, LJ Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa. ACS Med Chem Lett 6:162-7 (2015) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50351506
Synonyms:
CHEMBL1823934
Type:
Small organic molecule
Emp. Form.:
C17H26N2O4S
Mol. Mass.:
354.464
SMILES:
O=C(CCCCCCCCCN=C=S)CC(=O)N[C@H]1CCOC1=O |r|
Structure:
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